کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5948086 | 1172376 | 2012 | 4 صفحه PDF | دانلود رایگان |

ObjectivesTo address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.MethodsWe genotyped for rs1333049, 4097 CHD-free participants including 3191 aged 65-86 years from the Three-City (3C) Study and 906 aged 59-71 years from the Vascular Aging Study (EVA). Plaque-free mean CCA-IMT and the presence of carotid plaques were assessed.ResultsIn multivariate analysis, each C allele copy of rs1333049 was associated with baseline carotid plaques (odds ratio (OR) = 1.24; 95% confidence interval (CI) = 1.13-1.36; p < 0.001) but not with baseline CCA-IMT (p = 0.19). Among the EVA participants, the C allele was associated with 4-year plaques progression (p = 0.04) but not with CCA-IMT progression.ConclusionThe chromosome 9p21 locus might influence CHD risk through carotid plaques development.
⺠We studied the link between rs1333049 and subclinical atherosclerosis in older adults. ⺠Carotid plaques and intima-media thickness were assessed by ultrasound examination. ⺠Common carotid intima-media thickness was precisely measured at a plaque-free site. ⺠The C allele of rs1333049 was associated with carotid plaques. ⺠Rs1333049 genotype was not associated with carotid intima-media thickness.
Journal: Atherosclerosis - Volume 222, Issue 1, May 2012, Pages 187-190