Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice

► Animal study investigating mTOR-inhibition for treatment of advanced atherosclerosis. ► Everolimus reduced inflammatory cell content locally but pre-existing atherosclerosis progressed obstructively. ► Anti-atherosclerotic efficiency of pharmacotherapeutic mTOR-inhibition is suggested stage-dependent. ► Higher potential might be obscured by concomitant hypercholesterolemia.