ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination

► Dietary ω-6 lipids exhibit both pro- and anti-atherogenic effects on vascular cells. ► ω-6 lipids are biological ligands peroxisome proliferators-activated receptors (PPAR). ► ω-6 lipids modulates PPAR turnover and transactivity in a ligand and time dependent mechanism. ► ω-6 lipids modulates reciprocal interaction of PPARs between PGC-1 and ubiquitination.