RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity

► RAGE deficiency inhibits post-injury vascular remodeling by activating AMPK pathway. ► Carotid ligation decreases p-AMPK and increases RAGE and ligands, which promotes SMCs proliferation and migration. ► RAGE/ligands mediates vascular remodeling by regulation of AMPK activity via LKB1 and STAT3.