Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A

► The SREBPs are novel regulators of endothelial lipase expression. ► VEGF-A inhibits endothelial lipase expression both in vitro and in vivo. ► VEGF-A increases HDL cholesterol in atherosclerosis prone LDLR−/−ApoB100/100 mice.