Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR−/−)

► The potential atherogenic effect of LCHP diet in apoE/LDLR−/− mice was studied. ► The LCHP-fed mice developed more extensive atherosclerosis than WD-fed mice. ► LCHP diet favors the development of unstable lesions in mice. ► LCHP diet increased inflammatory component and decreased collagen content in plaque.