Expression and regulation of 12/15-lipoxygenases in human primary macrophages

► Which genes for 12/15-lipoxygenase activity in human primary macrophages? ► Polarized M2 macrophages express ALOX15 and ALOX15B. ► Polarized M1 macrophages and hypoxic macrophages only express ALOX15B. ► Human macrophages seem to mainly express ALOX15B.