کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5949045 1172385 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure
چکیده انگلیسی

ObjectivesArterial pressure induced vein graft injury can result in endothelial loss, accelerated atherosclerosis and vein graft failure. Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling.MethodsHuman saphenous vein graft segments (n = 8) were perfused in vitro with autologous blood either supplemented or not with purified human C1inh at arterial pressure for 6 h. The vein segments and perfusion blood were analyzed for cell damage and complement activation. In addition, the effect of purified C1inh on vein graft remodeling was analyzed in vivo in atherosclerotic C57Bl6/ApoE3 Leiden mice, wherein donor caval veins were interpositioned in the common carotid artery.ResultsApplication of C1inh in the in vitro perfusion model resulted in significantly higher blood levels and significantly more depositions of C1inh in the vein wall. This coincided with a significant reduction in endothelial loss and deposition of C3d and C4d in the vein wall, especially in the circular layer, compared to vein segments perfused without supplemented C1inh. Administration of purified C1inh significantly inhibited vein graft intimal thickening in vivo in atherosclerotic C57Bl6/ApoE3 Leiden mice, wherein donor caval veins were interpositioned in the common carotid artery.ConclusionC1inh significantly protects against early vein graft remodeling, including loss of endothelium and intimal thickening. These data suggest that it may be worth considering its use in patients undergoing coronary artery bypass grafting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 220, Issue 1, January 2012, Pages 86-92
نویسندگان
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