کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5949125 | 1172385 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden](/preview/png/5949125.png)
ObjectiveStress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress.MethodsWe recruited 47 lean and obese runners for a 10 week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA.ResultsWe found a significant increase of CGA (+51%; p < 0.01) in lean runners after marathon. The obese group showed the highest troponin T (0.22 ng/ml; p < 0.01) and proBNP (176.6 ng/ml; p < 0.01) levels. There were no correlations between proBNP, troponin T and CGA. An inverse correlation (r = â0.45; p < 0.01) was found between CGA and finishing times.ConclusionMarathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress.
Journal: Atherosclerosis - Volume 220, Issue 1, January 2012, Pages 219-222