Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat: Role of vitamin D metabolites

Pravastatin and atorvastatin have opposite effects on insulin sensitivity and vitamin D3 status. Pravastatin-induced increase in insulin sensitivity is mediated by elevation of 1,25-(OH)2-D3. In contrast, atorvastatin-induced decrease in insulin sensitivity is independent of lowering 25-OH-D3.