کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5949324 | 1172387 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia](/preview/png/5949324.png)
ObjectiveAtherogenic dyslipidemia is highly associated with coronary heart disease and is characterized by elevated triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C), and elevated low-density lipoprotein cholesterol (LDL-C). The combination of statins and fibrates is a common modality to treat individuals with atherogenic dyslipidemia.We sought to identify single nucleotide polymorphisms (SNPs) associated with HDL-C, TG, and apolipoprotein A1 (ApoA-I) response to combination therapy with statins and fenofibric acid (FA) in individuals with atherogenic dyslipidemia.Methods2228 individuals with mixed dyslipidemia who were participating in a multicenter, randomized, double-blind, active-controlled study comparing FA alone, in combination with a statin, or statin alone for a 12-week period, were genotyped for 304 candidate SNPs. A multivariate linear regression analysis for percent change in HDL-C, ApoA-I and TG levels was performed.ResultsSNPs in the apolipoprotein (APO) A5-ZNF259 region rs3741298 (PÂ =Â 1.8Â ÃÂ 10â7), rs964184 (PÂ =Â 3.6Â ÃÂ 10â6), rs651821 (PÂ =Â 4.5Â ÃÂ 10â5), and rs10750097 (PÂ =Â 1Â ÃÂ 10â4), were significantly associated with HDL-C response to combination therapy with statins and FA, with a similar association identified for ApoA-I. A haplotype composed of the minor alleles of SNPs rs3741298, rs964184, and rs10750097, was associated with a positive response to statins and FA (PÂ =Â 8.7Â ÃÂ 10â7) and had a frequency of 18% in the study population.ConclusionIn a population with atherogenic dyslipidemia, common SNPs and haplotypes within the APOA5-ZNF259 region are highly associated with HDL-C and ApoA-I response to combination therapy with statins and FA.
Journal: Atherosclerosis - Volume 219, Issue 2, December 2011, Pages 737-742