Ambulatory blood pressure variability is associated with restenosis after percutaneous coronary intervention in normotensive patients

BackgroundPrevious studies have showed that BP variability is associated with cardiovascular events. However, no data were available regarding binary restenosis as an end-point after percutenous coronary intervention (PCI).Methods and resultsThis multicenter study included 100 consecutive normotensive patients with stable coronary artery disease who were planned for PCI. Before the index procedure, office BP and 24-h ambulatory BP measurements were performed. BP variability indices including systolic and diastolic 24-h average, the day and the night values of standard deviation (SD) and variation coefficient (VC) were measured and calculated. All patients underwent repeat coronary angiography at 6-month. According to angiographic results, 2 groups were formed; a restenosis group (n = 30) with binary restenosis of the stented segment and a control group (n = 70) with a stenosis diameter of <50% in stented segment. Systolic SD and VC values for 24-h average (14.0 ± 2.8 mmHg vs. 9.5 ± 1.6 mmHg, p < 0.001 and 16% ± 3 vs. 11% ± 2, p < 0.001, respectively), the day (15.2 ± 3.9 mmHg vs. 10.6 ± 1.7 mmHg, p < 0.001 and 17% ± 4 vs. 12% ± 2, p < 0.001, respectively), and the night (12.8 ± 4.1 mmHg vs. 8.4 ± 2.4 mmHg, p < 0.001 and 14% ± 5 vs. 11% ± 3, p = 0.004, respectively) values were significantly higher in restenosis group compared to control group. Similarly, diastolic SD and VC values for 24-h average (10.6 ± 2.5 mmHg vs. 8.1 ± 1.5 mmHg, p < 0.001 and 12% ± 3 vs. 9% ± 2, p = 0.001, respectively), the day (11.1 ± 2.9 mmHg vs. 9.0 ± 1.8 mmHg, p = 0.003 and 12% ± 3 vs. 10% ± 2, p = 0.006, respectively), and the night (10.0 ± 3.6 mmHg vs. 7.2 ± 2.0 mmHg, p = 0.001 and 11% ± 5 vs. 9% ± 3, p = 0.059, respectively) values were significantly higher in restenosis group compared to no restenosis group except for diastolic VC night. All systolic and diastolic BP variability indices except diastolic VC night were found to be independent predictors of risk of restenosis in multivariate analysis. In addition, the cut-off values of 11.4 mmHg and 13% for 24-h systolic SD and VC, respectively, were found to be highly sensitive (93% for both) and specific (94% and 91%, respectively) for predicting binary restenosis at 6-month after PCI.ConclusionsBP variability indices are significantly and independently associated with binary restenosis and higher values can predict restenosis after PCI sensitively and specifically.