کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5950558 1172399 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline
چکیده انگلیسی

BackgroundBoth statins and ezetimibe lower LDL-C, but ezetimibe's effect on atherosclerosis is controversial. We hypothesized that lowering LDL-C cholesterol by adding ezetimibe to statin therapy would regress atherosclerosis measured by magnetic resonance imaging (MRI) in the superficial femoral artery (SFA) in peripheral arterial disease (PAD).MethodsAtherosclerotic plaque volume was measured in the proximal 15-20 cm of the SFA in 67 PAD patients (age 63 ± 10, ABI 0.69 ± 0.14) at baseline and annually × 2. Statin-naïve patients (n = 34) were randomized to simvastatin 40 mg (S, n = 16) or simvastatin 40 mg + ezetimibe 10 mg (S + E, n = 18). Patients already on statins but with LDL-C >80 mg/dl had open-label ezetimibe 10 mg added (E, n = 33). Repeated measures models estimated changes in plaque parameters over time and between-group differences.ResultsLDL-C was lower at year 1 in S + E (67 ± 7 mg/dl) than S (91 ± 8 mg/dl, p < 0.05), but similar at year 2 (68 ± 10 mg/dl vs. 83 ± 11 mg/dl, respectively). Plaque volume did not change from baseline to year 2 in either S + E (11.5 ± 1.4-10.5 ± 1.3 cm3, p = NS) or S (11.0 ± 1.5-10.5 ± 1.4 cm3, p = NS). In E, plaque progressed from baseline to year 2 (10.0 ± 0.8-10.8 ± 0.9, p < 0.01) despite a 22% decrease in LDL-C.ConclusionsStatin initiation with or without ezetimibe in statin-naïve patients halts progression of peripheral atherosclerosis. When ezetimibe is added to patients previously on statins, peripheral atherosclerosis progressed. Thus, ezetimibe's effect on peripheral atherosclerosis may depend upon relative timing of statin therapy.Clinical Trial Registration Information - NCT00587678 http://clinicaltrials.gov/ct2/show/NCT00587678.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 218, Issue 1, September 2011, Pages 156-162
نویسندگان
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