کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5950971 1172406 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of menopause and cholesteryl ester transfer protein (CETP) TaqIB polymorphism on lipid profile and HDL subpopulations distribution in women with and without type 2 diabetes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Influence of menopause and cholesteryl ester transfer protein (CETP) TaqIB polymorphism on lipid profile and HDL subpopulations distribution in women with and without type 2 diabetes
چکیده انگلیسی

The common TaqIB variant in the gene coding for cholesteryl ester transfer protein (CETP), a key enzyme in reverse cholesterol transport, has been associated with higher HDL-C levels and with a more atheroprotective HDL subpopulations profile. Similar information are lacking in women with diabetes. The effect of menopause and the CETP polymorphism on lipid, lipoprotein profile, as well as on apoA-I-containing HDL subclasses distribution, as determined by two-dimensional gel electrophoresis, was examined in a group of women with and without type 2 diabetes.Diabetic women showed a less atheroprotective lipid and HDL subpopulations profile, with lower levels of the large α-1 (P = 0.006), α-2 (P = 0.005), and preα-1 (P = 0.02), and higher concentration of the small α-3 HDL particles (P = 0.02) as compared to controls, independently from menopause, HDL-C and triglycerides concentrations.CETP TaqIB genotype distribution was in the Hardy-Weinberg equilibrium and comparable in the two groups, but the effect of CETP polymorphism was limited to diabetic women. In this group, the CETP variant showed significant interactions with HOMAIR (P < 0.001), BMI (P < 0.001), and triglycerides (P < 0.00001), with significantly higher HDL-C levels and a more protective HDL subpopulations profile in B2 allele carriers with lower HOMAIR, BMI or triglycerides levels.At multivariate analysis, CETP polymorphism, apoA-I, triglycerides and BMI were independent determinants of HDL-C concentration in diabetic women; apo-A-I, triglycerides, age and creatinine in controls.Type 2 diabetes is associated with a more atherogenic lipid profile; the CETP TaqIB variant may partly prevent these modifications in diabetic women with a milder degree of insulin resistance and its related disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 210, Issue 1, May 2010, Pages 294-301
نویسندگان
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