کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5951963 1173119 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased and inactivated nuclear factor kappa B 1 (p50) in human degenerative calcified aortic valve
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Decreased and inactivated nuclear factor kappa B 1 (p50) in human degenerative calcified aortic valve
چکیده انگلیسی

BackgroundDegenerative aortic valve calcification is an important factor in aortic stenosis and incompetence, but the pathogenesis is unclear. The purpose of the present study was to observe the expression of p50 in degenerative calcified aortic valves, which may provide a potential therapeutic target.MethodsFifteen cases of degenerative calcified aortic valve constituted the experimental group, and 10 aortic valves from patients who had undergone the Bentall operation constituted the control group.ResultsImmunostaining demonstrated that α-smooth muscle actin was highly expressed in valvular interstitial cells in the experimental group and that the percentage of CD68-positive cells was significantly higher in degenerative calcified aortic valves. Using bone gamma-carboxyglutamate protein as a marker of calcification showed that osteoblasts were significantly increased in the experimental valves. Western blot showed that p50 was more highly expressed and activated in the control group compared with the experimental group. Immunohistochemistry confirmed this finding and showed that p50 was principally localized to the endothelial cells of uncalcified valves, suggesting that it might play an important role in maintaining valve function.ConclusionsInhibition of p50 activity in endothelial cells might lead to calcification in degenerative calcified aortic valves.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cardiovascular Pathology - Volume 22, Issue 1, January–February 2013, Pages 28-32
نویسندگان
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