کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5964144 | 1576130 | 2016 | 10 صفحه PDF | دانلود رایگان |
BackgroundIn-stent restenosis (ISR) remains an important concern despite the recent advances in the drug-eluting stent (DES) technology. The introduction of drug-eluting balloons (DEB) offers a good solution to such problem.ObjectivesWe performed a meta-analysis to assess the clinical efficiency and safety of DEB compared with DES in patients with DES-ISR.MethodsA systematic search was conducted and all randomized and observational studies which compared DEB with DES in patients with DES-ISR were included. The primary outcome measure-major adverse cardiovascular events (MACE)-as well as individual events as target lesion revascularization (TLR), stent thrombosis (ST), myocardial infarction (MI), cardiac death (CD) and all-cause mortality, were analyzed.ResultsThree randomized and 4 observational studies were included with a total of 2052 patients. MACE (relative risk [RR]Â =Â 1.00, 95% confidence interval (CI) 0.68 to 1.46, PÂ =Â 0.99), TLR (RRÂ =Â 1.15 [CI 0.79 to 1.68], PÂ =Â 0.44), ST (RRÂ =Â 0.37[0.10 to 1.34], PÂ =Â 0.13), MI (RRÂ =Â 0.97 [0.49 to 1.91], PÂ =Â 0.93) and CD (RRÂ =Â 0.73 [0.22 to 2.45], PÂ =Â 0.61) were not different between patients treated with DEB and with DES. However, all-cause mortality was lower in patients treated with DEB (RRÂ =Â 0.45 [0.23 to 0.87, PÂ =Â 0.019) and in particular when compared to only first generation DES (RR 0.33 [0.15-0.74], PÂ =Â 0.007). There was no statistical evidence for publication bias.ConclusionsThe results of this meta-analysis showed that DEB and DES have similar efficacy and safety for the treatment of DES-ISR.
Journal: International Journal of Cardiology - Volume 218, 1 September 2016, Pages 126-135