کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5971502 | 1576184 | 2014 | 5 صفحه PDF | دانلود رایگان |
- Transcatheter ablation decreased the prevalence of Wolff-Parkinson-White syndrome.
- The prevalence increased after 5Â years of age and peaked at 21-40Â years of age.
- After the peak in young adults, the prevalence decreased with aging.
- Ebstein's anomaly and myocardial dysfunction are risk factors of mortality.
BackgroundThe prevalence of Wolff-Parkinson-White (WPW) syndrome varies between 0.68 and 1.7/1000. The epidemiological profile may be modified after the introduction of transcatheter interventions.ObjectivesThe aim of this study is to investigate the epidemiological trends of the WPW syndrome in a general population during a period with available and reimbursed transcatheter ablation.Methods and resultsData of WPW patients <Â 50Â years old were retrieved from our national database (2000-2010). We identified 6086 (61% male) patients, accounting for an overall prevalence of 0.36/1000 with a peak of 0.61/1000 in ages 20-24Â years. The risk of death and sudden death was 0.071% and 0.02% per patient-year, respectively. The 42 deaths occurred at a median age of 29Â years. Associated congenial heart disease was noted in 158 (2.6%) patients, including 42 with Ebstein's anomaly that increased the mortality risk (PÂ =Â 0.001, ORÂ =Â 8.5). In those without congenital heart disease, myocardial dysfunction occurred in 115 (1.9%) patients and increased the risk of death (PÂ <Â 0.001, ORÂ =Â 10.6) and sudden death. Radiofrequency catheter ablation was performed in 2527 patients at a median age of 25.7Â years (4.54% per patient-year, discharge mortality 0.16%); 11 (0.4%) before the age of 5, and 2231 (88%) after the age of 15. Whereas repeated ablation procedures accounted for 6.0% of the procedures, those in Ebstein's patients were 25%.ConclusionRadiofrequency catheter ablation is already a common treatment for WPW patients, particularly during young adulthood, which accounts for a lower prevalence. Myocardial dysfunction and associated congenital heart disease remain as risks of mortality.
Journal: International Journal of Cardiology - Volume 174, Issue 3, 1 July 2014, Pages 530-534