کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5979785 | 1576331 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prognostic value of flow-mediated dilatation following myocardial infarction Prognostic value of flow-mediated dilatation following myocardial infarction](/preview/png/5979785.png)
BackgroundRisk stratification for subsequent cardiovascular events following a myocardial infarction (MI) is an important area of research. Previous findings indicate flow-mediated dilatation (FMD) may be a valuable prognostic indicator. This study investigates the prognostic value of FMD in patients suffering an uncomplicated MI.MethodsOne hundred and seventy nine post-MI patients [110male/69 female, mean age: 64.8 ± 10.0 years, ejection fraction: 51.9 ± 12.2%] were included in this analysis. Ultrasound images of the brachial artery were used to determine FMD following reactive hyperemia. Subjects were tracked for subsequent cardiovascular events [myocardial infarction, heart failure, additional interventions (percutaneous coronary intervention, coronary artery bypass)] following data collection via medical chart review.ResultsThere were 45 subsequent cardiovascular events during a mean tracking period of 13.7 (± 9.5) months. Receiver operating characteristic (ROC) curve analysis revealed a diagnosis of diabetes (ROC area: 0.67, p = 0.001, 95% confidence interval: 0.58-0.77) and percent change in arterial diameter (ROC area: 0.63, p = 0.01, 95% confidence interval: 0.53-0.73, optimal threshold: â¤/> 4.5%) were prognostically significant. Kaplan-Meier analysis revealed the event-free survival rate for subjects without diabetes and an arterial diameter change > 4.5%, without diabetes and percent change in arterial diameter â¤Â 4.5%, with diabetes and percent change in arterial diameter > 4.5% and with diabetes and percent change in arterial diameter â¤Â 4.5% was 88.7%, 78.4%, 67.7% and 38.5%, respectively (Log-rank: 24.9, p < 0.0001).ConclusionsNon-invasive FMD is a potential risk factor after MI and may add information to conventional risk stratification. This will need to be tested in further studies.
Journal: International Journal of Cardiology - Volume 132, Issue 1, 6 February 2009, Pages 45-50