کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5979798 1576331 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness
چکیده انگلیسی

BackgroundAdvanced glycation end products (AGEs) and its receptor (RAGE) were known to play a pivotal role in the development of cardiovascular complications of diabetes. We investigated the association between circulating endogenous secretory RAGE (esRAGE) levels, inflammatory markers and arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV).MethodsThe study subjects were composed of 76 type 2 diabetic patients and 78 age- and sex-matched non-diabetic subjects.ResultsCirculating esRAGE levels were significantly lower in subjects with type 2 diabetes (0.237 ± 0.123 ng/ml vs. 0.307 ± 0.177 ng/ml, p = 0.005), and those levels were inversely correlated with body mass index (BMI), waist circumference, blood pressure, triglyceride, fasting glucose level and insulin resistance. Furthermore, esRAGE levels were significantly associated with adiponectin (r = 0.164, p = 0.044), interleukin-6 (IL-6) (r = − 0.242, p = 0.009) levels and baPWV (r = − 0.296, p < 0.001). Multiple regression analysis showed that fasting insulin, IL-6, glucose level and insulin resistance are major factor determining esRAGE (R2 = 0.186). Moreover, baPWV was found to be associated with age, systolic blood pressure, triglyceride, sex, BMI, fasting insulin and esRAGE level (R2 = 0.583).ConclusionsCirculating esRAGE levels were significantly lower in type 2 diabetic patients, and were associated with inflammation and arterial stiffness. These results suggest that esRAGE may play an important role on ligand-RAGE interaction propagated inflammation and atherosclerosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 132, Issue 1, 6 February 2009, Pages 96-101
نویسندگان
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