کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5982573 1577052 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using Age- and Sex-Specific Risk Thresholds to Guide Statin Therapy: One Size May Not Fit All
ترجمه فارسی عنوان
با استفاده از آستانه ریسک سن و جنس به راهنمای استاتین درمان: یک اندازه ممکن است همه مناسب نیست
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundNew cholesterol guidelines emphasize 10-year risk of cardiovascular disease (CVD) to identify adults eligible for statin therapy as primary prevention. Whether these CVD risk thresholds should be individualized by age and sex has not been explored.ObjectivesThis study evaluated the potential impact of incorporating age- and sex-specific CVD risk thresholds into current cholesterol guidelines.MethodsUsing data from the Framingham Offspring Study, this study assessed current treatment recommendations among age- and sex-specific groups in 3,685 participants free of CVD. Then, it evaluated how varying age- and sex-specific 10-year CVD risk thresholds for statin treatment affect the sensitivity and specificity for incident 10-year CVD events.ResultsBasing statin therapy recommendations on a 10-year fixed risk threshold of 7.5% results in lower statin consideration among women than men (63% vs. 33%; p < 0.0001), yet most of the study participants who were 66 to 75 years of age were recommended for statin treatment (90.3%). The fixed 7.5% threshold had relatively low sensitivity for capturing 10-year events in younger women and men (40 to 55 years of age). Sensitivity of the recommendations was substantially improved when the treatment threshold was reduced to 5% in participants who were 40 to 55 years of age. Among older adults (66 to 75 years of age), specificity was poor, but when the treatment threshold was raised to 10% in women and 15% in men, specificity significantly improved, with minimal loss in sensitivity.ConclusionsCholesterol treatment recommendations could be improved by using individualized age- and sex-specific CVD risk thresholds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 65, Issue 16, 28 April 2015, Pages 1633-1639
نویسندگان
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