کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5986046 1178792 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of preprocedural low-density lipoprotein cholesterol levels with myocardial injury after elective percutaneous coronary intervention
ترجمه فارسی عنوان
بررسی ارتباط سطح کلسترول لیپوپروتئین با چگالی قبل از مداخله با آسیب قلبی بعد از مداخله عروق کرونر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

►First study assessed the relation of LDL-C with myocardial injury related to PCI.►Low LDL-C levels were associated with less risk of myocardial injury following PCI.►A guideline LDL-C level of <100 mg/dl related to less myocardial injury after PCI.►An optimal LDL-C level of <70 mg/dl strongly related to less myocardial injury.►Unstable angina was associated with less risk of myocardial injury following PCI.

BackgroundLower levels of low-density lipoprotein cholesterol (LDL-C) are associated with less cardiovascular risk in patients with coronary artery disease.ObjectivesTo assess whether lower preprocedural LDL-C levels are associated with less risk of periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention (PCI).MethodsWe enrolled 2529 consecutive patients with normal preprocedural cardiac troponin I (cTnI) who successfully underwent elective PCI. The association between preprocedural LDL-C levels and peak cTnI levels within 24 hours after PCI was evaluated.ResultsPreprocedural LDL-C levels were correlated to postprocedural cTnI levels (r = 0.059, P = .003). In the multivariable model, preprocedural LDL-C levels between 70 and 99 mg/dL were associated with less risk of postprocedural cTnI elevation above 1 × upper limit of normal (ULN) (odds ratio [OR]: 0.804; 95% confidence interval [CI]: 0.663-0.975; P = .027) up to 15 × ULN (OR: 0.709; 95% CI: 0.530-0.949; P = .021) compared with preprocedural LDL-C levels ≥100 mg/dL. Moreover, preprocedural LDL-C levels <70 mg/dL were more strongly associated with less risk of postprocedural cTnI elevation above 1 × ULN (OR: 0.736; 95% CI: 0.584-0.927; P = .009) up to 15 × ULN (OR: 0.655; 95% CI: 0.452-0.950; P = .026).ConclusionsLower preprocedural LDL-C levels were associated with less risk of periprocedural myocardial injury in patients undergoing elective PCI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Lipidology - Volume 8, Issue 4, July–August 2014, Pages 423-432
نویسندگان
, , , , , , , , , , , , ,