کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5986107 1178806 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apple pectin for the reduction of niacin-induced flushing
ترجمه فارسی عنوان
پکتین اپل برای کاهش ته نشینی ناشی از نیاسین
کلمات کلیدی
پکتین اپل، آسپرین کلسترول، سوزش پوستی، نیاسین،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundNiacin, or vitamin B3, when used in high doses can significantly improve the levels of all major lipoproteins. Despite these benefits, the use of niacin is greatly limited secondary to benign yet bothersome cutaneous flushing primarily involving the face and upper extremities. Pretreatment with aspirin or other prostaglandin inhibitors has demonstrated significant reductions in niacin-induced flushing (NIF), but other treatment options are needed. Clinical and anecdotal evidence suggests the ingestion of pectin-containing fruits (eg, apple) mitigates NIF; however, clinical trials evaluating this are nonexistent.ObjectiveThat pretreatment with encapsulated apple pectin would limit the incidence, severity, time of initiation, and duration of NIF.MethodsWe enrolled 100 niacin-naïve subjects (n = 25 per group) and preteated them in a double-blind manner with apple pectin, apple pectin + aspirin, aspirin, or placebo, followed by a one-time 1000 mg dose of niacin extended-release (niacin ER). Subjects then assessed major flushing parameters hourly for the next 6 hours with a validated visual analog scale.ResultsApple pectin and aspirin each significantly lowered the duration of NIF and produced nonsignificant but positive improvements in all other major flushing parameters compared with placebo.ConclusionApple pectin may potentially be an alternative to aspirin for the prevention of NIF. Larger trials are needed to further evaluate the benefit of pectin on NIF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Lipidology - Volume 7, Issue 2, March–April 2013, Pages 140-146
نویسندگان
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