Comparative studies on exenatide-loaded poly (d,l-lactic-co-glycolic acid) microparticles prepared by a novel ultra-fine particle processing system and spray drying

- Introduced ultra-fine particle processing system (UPPS) to prepare microparticles.
- Compared properties of microparticles (MPs) prepared by UPPS and spray drying.
- Prepared exenatide-loaded PLGA-MPs showed sustained antidiabetic effect.
- UPPS is benefit to protecting the encapsulated proteins during preparation.