Quantification of aldehyde terminated heparin by SEC-MALLS-UV for the surface functionalization of polycaprolactone biomaterials

- Heparin depolymerization methods are compared for optimal grafting onto PCL strips.
- SEC-MALLS-UV facilitates detection of aldehydes and Schiff-base functional groups.
- L.S., R.I., and U.V. detectors allow quantifiable characterization of analytes.
- Reaction optimized for minimal polydispersity, high yield and antithrombin activity.