کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599420 1454275 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents
ترجمه فارسی عنوان
آماده سازی و مشخصه درون سلول های نانو بوته های کیتوزان به عنوان عوامل تری آنستیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Theranostic chitosan-shelled and perfluoropentane-filled nanobubble system.
• Efficient co-incorporation of PLP and a Gd complex, as therapeutic and MRI agent.
• Prolonged in vitro drug release kinetics enhanced by US application.
• Good in vitro echogenicity of the theranostic nanobubbles due to ADV phenomenon.
• Ability of theranostic nanobubbles to generate positive MRI contrast.

Theranostic delivery systems are nanostructures that combine the modality of therapy and diagnostic imaging. Polymeric micro- and nanobubbles, spherical vesicles containing a gas core, have been proposed as new theranostic carriers for MRI-guided therapy. In this study, chitosan nanobubbles were purposely tuned for the co-delivery of prednisolone phosphate and a Gd(III) complex, as therapeutic and MRI diagnostic agent, respectively. Perfluoropentane was used for filling up the internal core of the formulation. These theranostic nanobubbles showed diameters of about 500 nm and a positive surface charge that allows the interaction with the negatively charged Gd-DOTP complex. Pluronic F68 was added to the nanobubble aqueous suspension as stabilizer agent. The encapsulation efficiency was good for both the active compounds, and a prolonged drug release profile was observed in vitro. The effect of ultrasound stimulation on prednisolone phosphate release was evaluated at 37 °C. A marked increase on drug release kinetics with no burst effect was obtained after the exposure of the system to ultrasound. Furthermore, the relaxivity of the MRI probe changed upon incorporation in the nanobubble shell, thereby offering interesting opportunity in dual MRI-US experiments. The ultrasound characterization showed a good in vitro echogenicity of the theranostic nanobubbles.In summary, chitosan drug-loaded nanobubbles with Gd(III) complex bound to their shell might be considered a new platform for imaging and drug delivery with the potential of improving anti-cancer treatments.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 129, 1 May 2015, Pages 39–46
نویسندگان
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