Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles

- Glycerosomes with different amounts of glycerol (from 10 to 50%) were prepared.
- SAXS showed a dose-dependent interaction of glycerol with phospholipid polar head.
- 40 and 50% glycerosomes were the most stable vesicular system.
- Glycerosomes protected keratinocytes from oxidative stress damage.
- 40 and 50% glycerosomes are promising carriers for topical delivery of quercetin.