Surface engineered nanostructured lipid carriers for targeting MDR tumor: Part I. Synthesis, characterization and in vitro investigation

- A novel alendronate-hyaluronic acid (AL-HA) graft polymer was synthesized by amide coupling.
- AL-HA graft polymer was assembled over irinotecan containing NLC by calcium assisted mineralization.
- Low IC50 values and enhanced uptake was found in P-gp overexpressing MDR cells.
- In vitro targeting CD-44 bio-receptor in HT-29 and Colo-320 cells.
- Modulation of ATPase pump and MDR1 gene expression in cancer cell lines.