Topical delivery of clobetasol propionate loaded microemulsion based gel for effective treatment of vitiligo - Part II: Rheological characterization and in vivo assessment through dermatopharmacokinetic and pilot clinical studies

- Microemulsion based gel (MBC) of clobetasol propionate (CP) was formualated.
- MBC was characterized by ex vivo permeation studies, rheological parameters and pilot clinical studies.
- MBC showed good retention in skin layers which was confirmed by CLSM studies and dermatopharmacokinetic studies.
- MBC was able to form repigmentation of patches in vitiligo patients.