Thermo-responsive hollow silica microgels with controlled drug release properties

- Novel thermo-responsive hollow silica microgels (THSMGs) were prepared.
- The porosity is still in the THSMGs after the coverage of PNIPAAm gels.
- THSMGs possess good thermosensitive performance in spite of rigid silica layer.
- THSMGs have good biocompatibility and achieve controlled release of RHB.
- THSMGs are a type of promising targeted drug delivery carriers.