کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5998915 1181455 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation between coronary perfusion pressure and quantitative ECG waveform measures during resuscitation of prolonged ventricular fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Correlation between coronary perfusion pressure and quantitative ECG waveform measures during resuscitation of prolonged ventricular fibrillation
چکیده انگلیسی

IntroductionThe ventricular fibrillation (VF) waveform is dynamic and predicts defibrillation success. Quantitative waveform measures (QWMs) quantify these changes. Coronary perfusion pressure (CPP), a surrogate for myocardial perfusion, also predicts defibrillation success. The relationship between QWM and CPP has been preliminarily explored. We sought to further delineate this relationship in our porcine model and to determine if it is different between animals with/without ROSC (return of spontaneous circulation).HypothesisA relationship exists between QWM and CPP that is different between animals with/without ROSC.MethodsUtilizing a prior experiment in our porcine model of prolonged out-of-hospital VF cardiac arrest, we calculated mean CPP, cumulative dose CPP, and percent recovery of three QWM during resuscitation before the first defibrillation: amplitude spectrum area (AMSA), median slope (MS), and logarithm of the absolute correlations (LAC). A random effects linear regression model with an interaction term CPP*ROSC investigated the association between CPP and percent recovery QWM and how this relationship changes with/without ROSC.ResultsFor 12 animals, CPP and QWM measures (except LAC) improved during resuscitation. A linear relationship existed between CPP and percent recovery AMSA (coefficient 0.27; 95%CI 0.23, 0.31; p < 0.001) and percent recovery MS (coefficient 0.80; 95%CI 0.70, 0.90; p < 0.001). A linear relationship existed between cumulative dose CPP and percent recovery AMSA (coefficient 2.29; 95%CI 2.0, 2.56; p < 0.001) and percent recovery MS (coefficient 6.68; 95%CI 6.09, 7.26; p < 0.001). Animals with ROSC had a significantly “steeper” dose-response relationship.ConclusionsThere is a linear relationship between QWM and CPP during chest compressions in our porcine cardiac arrest model that is different between animals with/without ROSC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Resuscitation - Volume 83, Issue 12, December 2012, Pages 1497-1502
نویسندگان
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