Effect of ionic liquids on the different hierarchical order of type I collagen

- The effect of imidazolium ILs on the hierarchical order of collagen is atypical.
- Secondary structure and fibril formation of collagen is unaffected at molecular level.
- Thermal stability of collagen fiber is decreased in the presence of ionic liquids.
- Imidazolium ILs reveal increased pore size of the skin, suggesting lyotropic action.
- ILs are potential for collagen-based biomaterials that require controlled, desired porosity materials.