کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599987 1454291 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced doxorubicin delivery and cytotoxicity in multidrug resistant cancer cells using multifunctional magnetic nanoparticles
ترجمه فارسی عنوان
تحویل دکسوروبیسین پیشرفته و سمیت سلولی در سلول های سرطانی مقاوم به چندین دارو با استفاده از نانوذرات مغناطیسی چند منظوره
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• New nanocarrier was developed for efficient delivery of anti-cancer drug.
• This system has advantages of simple and efficient drug loading in native format.
• This system shows enhanced efficacy against multidrug resistance cells.
• This system has great potential as the next generation of cancer treatment.

Carboxymethyl modified magnetic nanoparticles (CMC-MNPs) have been designed as a vehicle for drug delivery in both drug-sensitive and drug-resistant cancer cells. We have demonstrated that the CMC-MNPs were able to load doxorubicin (DOX) with a high loading efficiency while also maintaining a good colloidal stability in an aqueous solution. According to a drug release study, DOX-loaded CMC-MNPs showed that the pH-dependent drug release property had a much higher release rate in acidic pH. Compared to free DOX, the DOX-loaded CMC-MNPs showed higher DOX accumulation in drug-sensitive cancer cells and much higher accumulation in drug-resistant cancer cells. These results indicate that our nanoplatform is highly efficient as a drug delivery system in both normal cancer cells and MDR cancer cells. In addition, the DOX-loaded CMC-MNPs can also enhance cytotoxicity against drug-resistant cancer cells in comparison to free DOX. The results obtained in this research demonstrate that our nanoplatform may be a promising approach in cancer chemotherapy and for overcoming multidrug-resistant cancer cells.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 113, 1 January 2014, Pages 249–253
نویسندگان
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