کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6000409 1579200 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells
ترجمه فارسی عنوان
همودینامیک مرتبط با فیبریلاسیون دهلیزی به طور مستقیم پتانسیل ترومبوتیک سلول های اندوتلیال را تغییر می دهد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- LAA atrial fibrillation (AFib) hemodynamics were applied to endothelial cells.
- AFib-exposed endothelial cells exhibited increased fibrin deposition.
- Markers of thrombosis are altered in AFib-exposed endothelial cells.
- Fibrin deposition thickness is reduced by apixaban in our experimental model.

An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AFib hemodynamic shear stress patterns to primary human endothelial cells (ECs) in culture. We found that ECs exposed to AFib hemodynamics have increased thrombotic potential as measured by increased expression of pro-thrombotic gene markers and fibrin deposition on the endothelium. Treatment with the factor Xa inhibitor, apixaban, attenuated fibrin deposition thickness while increasing fibrin density at the endothelial cell surface. This study suggests that altered hemodynamics associated with AFib play a key role in driving the thrombotic potential of the LAA endothelium.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 143, July 2016, Pages 34-39
نویسندگان
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