کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
600213 | 1454299 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Release kinetics of 5-aminosalicylic acid from halloysite Release kinetics of 5-aminosalicylic acid from halloysite](/preview/png/600213.png)
This paper investigates desorption of 5-aminosalicilyc acid (5-ASA) adsorbed onto halloysite (HL). Desorption isotherms were fitted according to kinetic laws obtained considering release of 5-ASA from HL as the phase of desorption of the previously adsorbed drug molecules both inside the nanotubes of HL as onto the surface of clay particles and/or in the inter-particle spaces of their aggregates [28]. Desorption isotherms has been also fitted with other equations frequently used in drug release kinetics studies. The best fitting corresponded to the kinetic model proposed; in agreement with the results of adsorption [28].
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► A novel mechanistic model for in vitro dissolution drug release is proposed.
► The proposed model adequately fits data of drug release from solid inorganic adsorbates.
► The postulated model arises from kinetic laws associated with physical–chemical processes in the solid–liquid interface.
► The proposed model provides real hypotheses about mechanisms implicated in drug release.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 105, 1 May 2013, Pages 75–80