کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6002399 1182968 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of multiligand/RAGE axis in platelet activation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Role of multiligand/RAGE axis in platelet activation
چکیده انگلیسی
In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end products (AGEs) significantly increases platelet activation and receptor for AGEs (RAGE) expression at the platelet surface membrane. In addition to AGEs, other ligands (S100, HMGB1 and amyloid β, among others) of RAGE have raised particular attention in platelet activation. Therefore, in this article we describe platelet hyperactivity by AGEs via RAGE-independent and RAGE-dependent pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 133, Issue 3, March 2014, Pages 308-314
نویسندگان
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