کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
600306 1454298 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltammetric oxidation and determination of atorvastatin based on the enhancement effect of cetyltrimethyl ammonium bromide at a carbon paste electrode
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Voltammetric oxidation and determination of atorvastatin based on the enhancement effect of cetyltrimethyl ammonium bromide at a carbon paste electrode
چکیده انگلیسی

An electrochemical method has been described for the voltammetric oxidation and determination of an antihyperlipoproteinemic drug, atorvastatin (ATOR), at a carbon paste electrode (CPE) in the presence of an enhancing agent, cetyltrimethyl ammonium bromide (CTAB) using cyclic and differential pulse voltammetry (DPV). The results indicated that the voltammetric response of ATOR was improved distinctly in the low concentration of CTAB, suggesting that CTAB exhibits noticeable enhancement effect to the determination of ATOR. The dependence of current on pH, concentration and scan rate were investigated to optimize the experimental conditions for the determination of ATOR. The anodic peak was characterized and the process was adsorption-controlled. The number of electrons transferred in the oxidation process was calculated and a plausible oxidation mechanism was proposed. In the range of 0.05–10 μM, the current measured by DPV presents a good linear property as a function of the concentration of ATOR with a detection limit of 4.08 nM with good selectivity and sensitivity. The proposed method was successfully applied to ATOR determination in pharmaceutical samples and urine as a real sample. This method can be employed in clinical analysis, quality control and routine determination of drugs in pharmaceutical formulations.

Figure optionsDownload as PowerPoint slideHighlights
► Carbon paste electrode in the presence of cetyltrimethyl ammonium bromide has been used for the voltammetric oxidation of an antihyperlipoproteinemic drug, atorvastatin.
► The electrode process was irreversible and adsorption controlled.
► For voltammetric determination of atorvastatin, the detection limit was found to be 4.08 nM.
► The method was used for the analysis of atorvastatin drug in pharmaceutical and urine samples.
► Proposed method is more sensitive in comparison to reported electroanalytical methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 106, 1 June 2013, Pages 158–164
نویسندگان
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