کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6004675 1184247 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats
چکیده انگلیسی

We evaluate the effects of chronic treatment with celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, on blood pressure (BP) and heart rate variability (HRV) in obese rats induced by neonatal monosodium glutamate (MSG). The animals were treated with celecoxib or saline for 30 days (from the 60th to the 90th day of age). On the 90th day, the MSG obesity induced an increase in the low-frequency (LF) component (CTR = 5.69 ± 18.30 ms2, MSG = 38.49 ± 6.27 ms2) and a decrease in the high-frequency (HF) component of HRV (CTR = 71.48 ± 6.22 ms2, MSG = 50.94 ± 7.03 ms2), which were unchanged by celecoxib treatment. We suggest that HRV in MSG obesity involves a greater sympathetic modulation not related with COX-2 products.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 165, Issue 2, 7 December 2011, Pages 201-204
نویسندگان
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