The influence of plant stanol (β-sitostanol) on inner leaflet of human erythrocytes membrane modeled with the Langmuir monolayer technique

► Phosphatidylserine/phosphatidylethanolamine/cholesterol as a model of inner membrane layer. ► β-sitostanol alters organization of model inner membrane layer. ► The presence of β-sitostanol leads to the formation of 3D crystallites within the model membrane. ► Limited solubility of plant stanol in phospholipids environment.