کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601132 879932 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controllable synthesis and characterization of porous polyvinyl alcohol/hydroxyapatite nanocomposite scaffolds via an in situ colloidal technique
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Controllable synthesis and characterization of porous polyvinyl alcohol/hydroxyapatite nanocomposite scaffolds via an in situ colloidal technique
چکیده انگلیسی

During the last decades, there have been several attempts to combine bioactive materials with biocompatible and biodegradable polymers to create nanocomposite scaffolds with excellent biocompatibility, bioactivity, biodegradability and mechanical properties. In this research, the nanocomposite scaffolds with compositions based on PVA and HAp nanoparticles were successfully prepared using colloidal HAp nanoparticles combined with freeze-drying technique for tissue engineering applications. In addition, the effect of the pH value of the reactive solution and different percentages of PVA and HAp on the synthesis of PVA/HAp nanocomposites were investigated. The SEM observations revealed that the prepared scaffolds were porous with three dimensional microstructures, and in vitro experiments with osteoblast cells indicated an appropriate penetration of the cells into the scaffold's pores, and also the continuous increase in cell aggregation on the scaffolds with increase in the incubation time demonstrated the ability of the scaffolds to support cell growth. According to the obtained results, the nanocomposite scaffolds could be considered as highly bioactive and potential bone tissue engineering implants.

Figure optionsDownload as PowerPoint slideResearch highlights
► Immediately, after addition of phosphate precursor to the PVA solution, the synthesis process of colloidal HAp nanoparticles were commenced.
► Changes of the pH value could manipulate the role of hydroxyl pendant groups on the PVA backbone as a nucleation site for HAp crystals.
► Penetration of the cells into the scaffold's pores confirming that the pore inlets were wide enough to allow entrance of osteoblast cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 84, Issue 2, 1 June 2011, Pages 310–316
نویسندگان
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