کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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601146 | 879932 | 2011 | 7 صفحه PDF | دانلود رایگان |

Drug–phospholipid lipid nanoparticles (DPLNs) are prepared by incorporating drug–phospholipid complexes (DPCs) with a liquid lipid. DPLNs demonstrated interesting properties including increased encapsulation capacity, improved stability and controlled drug release profile. A comprehensive characterization of DPLNs was presented and then a schematic model was suggested according to the characterization results. Transmission electron microscopy and scanning electron microscope measurements showed the morphology of DPLNs. X-ray diffraction exhibited a predominantly amorphous structure for DPCs and totally amorphous for DPLNs. Laser confocal scanning microscopy revealed the relative position of DPCs and liquid lipid, showing that DPLNs formed a homogeneous system. Fluorescence spectra and electron spin resonance further confirmed the chemical environment inside the DPLNs in a non-invasive way.
A novel nanoparticle is constituted of amorphous lipids, yielding high drug loading, excellent encapsulation effect and impressive stable capacity. The micro-structure is totally amorphous homogeneous.Figure optionsDownload as PowerPoint slideResearch highlights
► A novel nanoparticle is constituted of amorphous lipids.
► The micro-structure is totally amorphous homogeneous.
► This drug delivery system is provided with high drug loading, excellent encapsulation effect and impressive stable capacity.
► Release of drug in this system fits erosion-controlled mechanism.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 84, Issue 2, 1 June 2011, Pages 406–412