کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601146 879932 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural characterization of novel phospholipid lipid nanoparticles for controlled drug delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Structural characterization of novel phospholipid lipid nanoparticles for controlled drug delivery
چکیده انگلیسی

Drug–phospholipid lipid nanoparticles (DPLNs) are prepared by incorporating drug–phospholipid complexes (DPCs) with a liquid lipid. DPLNs demonstrated interesting properties including increased encapsulation capacity, improved stability and controlled drug release profile. A comprehensive characterization of DPLNs was presented and then a schematic model was suggested according to the characterization results. Transmission electron microscopy and scanning electron microscope measurements showed the morphology of DPLNs. X-ray diffraction exhibited a predominantly amorphous structure for DPCs and totally amorphous for DPLNs. Laser confocal scanning microscopy revealed the relative position of DPCs and liquid lipid, showing that DPLNs formed a homogeneous system. Fluorescence spectra and electron spin resonance further confirmed the chemical environment inside the DPLNs in a non-invasive way.

A novel nanoparticle is constituted of amorphous lipids, yielding high drug loading, excellent encapsulation effect and impressive stable capacity. The micro-structure is totally amorphous homogeneous.Figure optionsDownload as PowerPoint slideResearch highlights
► A novel nanoparticle is constituted of amorphous lipids.
► The micro-structure is totally amorphous homogeneous.
► This drug delivery system is provided with high drug loading, excellent encapsulation effect and impressive stable capacity.
► Release of drug in this system fits erosion-controlled mechanism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 84, Issue 2, 1 June 2011, Pages 406–412
نویسندگان
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