کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601252 879935 2011 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular biocompatibility evaluation of poly(d,l-lactic acid)-modified biomaterials based on long serial analysis of gene expression
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Molecular biocompatibility evaluation of poly(d,l-lactic acid)-modified biomaterials based on long serial analysis of gene expression
چکیده انگلیسی
► Long serial analysis of gene expression (LongSAGE) technology was used to investigate the molecular mechanism of the interaction between cells and poly(d,l-lactic acid)-modified biomaterials. ► Surface modification of MPLA biomaterial has an extensive influence on cells by regulating expression of genes related to cell proliferation, cell cycle, cytoskeleton organization, ossification, bone remodeling, metabolism, and eventually induces osteoblast proliferation and differentiation. ► This work provides a new method to investigate the molecular mechanism of the interaction of cell-biomaterial or evaluate the molecular biocompatibility of biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 85, Issue 2, 1 July 2011, Pages 248-261
نویسندگان
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