Electrochemical behavior and voltammetric determination of paracetamol on Nafion/TiO2–graphene modified glassy carbon electrode

The TiO2–graphene (TiO2–GR) nanocomposite for paracetamol electrochemical sensing is described. The electrochemical behavior of paracetamol at the Nafion/TiO2–GR composite film modified glassy carbon electrode (GCE) was investigated by cyclic voltammetry. The results showed that the incorporation of TiO2 nanoparticles with graphene significantly enhanced the electrochemical reactivity and voltammetric response of paracetamol. In addition, Nafion acts as an effective solubilizing agent and antifouling coating in the fabrication of the modified electrode. This electrochemical sensor exhibits excellent analytical performance for paracetamol detection at physiological pH with detection limit of 2.1 × 10−7 M, linear range of 1–100 μM and reproducibility of 3.6% relative standard deviation.

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► Incorporation of TiO2 with graphene increases the electrochemical sensing performance.
► Paracetamol exhibits enhanced reactivity on the Nafion/TiO2–GR composite film.
► Paracetamol can be detected with low detection limit and wide linear range.