Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

► The mixed micelles composed of F127-CL copolymer and BSA or PLA display good thermosensitivity. ► The release of DOX.HCl from the micelles is faster in mildly acidic physiological environments than that at pH 7.4. ► The micelles possess excellent biocompatibility. ► The DOX.HCl-loaded micelles are effective to inhibit the growth of HepG2 tumor cells.