Short communicationExpression of DNA methylation genes in secondary progressive multiple sclerosis

- MBD2 and MBD4 are upregulated in PBMCs of SP MS patients.
- TDG and TET3 are downregulated in PBMCs of SP MS patients.
- In SP MS there is a correlation between TET3 levels and APLP2, SLC25A11 and ATP6AP2.

Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.

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