کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020393 1580397 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE
چکیده انگلیسی


- BMDCs and T cells accumulate and interact in specific brain regions in early EAE.
- DCs and T cells accumulate in periventricular brain tissues before spinal cord.
- Immune cell migration through RMS is increased during neuroinflammation.
- We identify primary and secondary CNS compartments of immune cell entry in EAE.

Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry portal. Moreover, despite emphasis on spinal cord inflammation in EAE and in correspondence with MS pathology, inflammatory lesions containing interacting DCs and T cells are present in specific brain regions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 277, Issues 1–2, 15 December 2014, Pages 39-49
نویسندگان
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