کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020432 1580406 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological role of Toll-like receptor-4 in the brain
ترجمه فارسی عنوان
نقش بیولوژیکی گیرنده -4 مانند مغز در مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
The Toll-like receptors (TLRs) are a family of microbe-sensing receptors that play a central role in the regulation of the host immune system. TLR4 has been described in the brain and seems to regulate some physiological processes, such as neurogenesis. TLR4 has also been reported to play a role during neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease. This review is focused on reports concerning recent insights into the role and activation mechanisms of TLR4 in the brain, in pathological and physiological conditions, as well as the therapeutic benefit that could derive from TLR4 modulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 268, Issues 1–2, 15 March 2014, Pages 1-12
نویسندگان
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