کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020467 | 1580409 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Leucine-rich glioma inactivated 1 (LGI1) was recently identified as a target protein in autoimmune synaptic encephalitis, a rare condition associated with autoantibodies against structures in the neuronal synapse. Studies dealing with LGI1 are small in number and the various outcomes of different therapeutic regimens are not well studied. Here, we analyzed clinical characteristics of 14 patients with LGI1 antibodies, and outcomes according to therapeutic strategies. Most patients exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treated with steroids and intravenous immunoglobulins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 265, Issues 1â2, 15 December 2013, Pages 75-81
Journal: Journal of Neuroimmunology - Volume 265, Issues 1â2, 15 December 2013, Pages 75-81
نویسندگان
Yong-Won Shin, Soon-Tae Lee, Jung-Won Shin, Jangsup Moon, Jung-Ah Lim, Jung-Ick Byun, Tae-Joon Kim, Keon-Joo Lee, Young-Su Kim, Kyung-Il Park, Keun-Hwa Jung, Sang Kun Lee, Kon Chu,