کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020610 1580412 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrathecal oligoclonal IgG synthesis in multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Intrathecal oligoclonal IgG synthesis in multiple sclerosis
چکیده انگلیسی
The diagnosis of multiple sclerosis is based on dissemination in time and space. Before 2010 lack of evidence for dissemination in space could be substituted by a paraclinical test, cerebrospinal fluid (CSF) oligoclonal bands (OCBs). The present meta-analysis (13,467 patients) shows that the diagnostic specificity of OCB drops from 94% to 61% if inflammatory etiologies are considered. Importantly, this was not caused by poor laboratory practice. This review on CSF OCB further illustrates the conceptional problem of substituting dissemination in space with a biomarker. The potential prognostic value of intrathecal OCB will need to be tested prospectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 262, Issues 1–2, 15 September 2013, Pages 1-10
نویسندگان
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