کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020770 | 1580420 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short communicationIncrease of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n = 15), multiple sclerosis (MS) (n = 15), and other neurological disease (OND) (n = 12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 254, Issues 1â2, 15 January 2013, Pages 178-182
Journal: Journal of Neuroimmunology - Volume 254, Issues 1â2, 15 January 2013, Pages 178-182
نویسندگان
Hiroshi Kuroda, Kazuo Fujihara, Rina Takano, Yoshiki Takai, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Shigeru Sato, Yasuto Itoyama, Masashi Aoki,