کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6021015 | 1580446 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9 Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9](/preview/png/6021015.png)
چکیده انگلیسی
To reduce the risk of an adverse T cell-mediated immune response to Aβ42, three (Aβ9)16-based recombinant immunogens were designed to immunize mice. Compared with Aβ42, they elicited significantly stronger anti-Aβ42 antibody responses and mainly resulted in IgG1 and IgG2b anti-Aβ42 antibodies. These (Aβ9)16-induced antibodies exhibited stronger abilities not only to inhibit Aβ42 aggregation and to disassemble Aβ42 aggregation, but also to inhibit and neutralize Aβ42-induced cytotoxicity in vitro though they showed higher specificities to Aβ42 monomers and Aβ42 oligomers. These results suggested that (Aβ9)16 was a promising candidate for the safe and effective primary immunogen against Aβ42.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 227, Issues 1â2, 8 October 2010, Pages 18-25
Journal: Journal of Neuroimmunology - Volume 227, Issues 1â2, 8 October 2010, Pages 18-25
نویسندگان
Lili Cui, Xuemei Huang, Jiapeng Wang, Yingjiu Zhang,